Holistic Quality
For regulators
Chemical-safety evidence you can cite, and check.
Every agency’s position on a substance, side by side, each tied to the agency’s own document, archived and dated. Free for regulatory bodies once our data meets our quality bar. We earn from brands and consultants, never from agencies.
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Every agency, one screen.
IARC, US EPA, EU CLP and ECHA, California OEHHA, EFSA, NTP: each agency’s classification for a substance, side by side. Where agencies disagree we show the disagreement; we never average it away.
Agency Position Source IARC Group 2B, "possibly carcinogenic to humans" (lung, inhalation) [S1] Vol. 93 EFSA E 171 "can no longer be considered as safe when used as a food additive" (2021) [S2] EU Food additive withdrawn from 2022 [S3] Reg. (EU) 2022/63 EU courts Carcinogen classification annulled; upheld on appeal 1 Aug 2025 [S4] US FDA Permitted in food, ≤ 1% by weight [S5] 21 CFR 73.575 ⚑ Disagreement flagged: food use, EU (not permitted) vs US (permitted ≤ 1%).
Example · titanium dioxide -
Legal limits by route, and who they bind.
Workplace air limits by sector (OSHA general industry, construction, shipyards), drinking-water limits and EU occupational limits, each with its exposure route and the regulation’s own text.
Route Limit Binds Source Workplace air 15 mg/m³ total dust, 8-hour TWA US employers, general industry and shipyards [S8] 29 CFR 1910.1000 Z-1; 1915.1000 (archived) Food ≤ 1% by weight US food [S5] Skin (sunscreen) ≤ 25% US and EU sunscreens [S6], [S9] (For contrast: NIOSH recommends 2.4 mg/m³ fine and 0.3 mg/m³ ultrafine [S7]. That is a recommendation, not a legal limit, and is labelled so. The construction table (1926) carries a TiO₂ total-dust row with no figure parsed, so it is not shown.)
Example · titanium dioxide -
Built for the people most at risk.
Hazard readings for pregnancy, infancy, childhood and old age, marked as our reading and shown beside the sources they rest on.
Adult Child Infant Pregnancy Inhalation Skin Ingestion low to moderate low low to moderate not assessed ("context dependent") moderate low low "Our reading; the sources behind it are listed on the record." A population we have not assessed says so. We do not fill it in.
Example · titanium dioxide -
Evidence for your case file.
A dated, citable export for any substance: every value, its source document, and an archived copy you can check against.
Titanium dioxide · CAS 13463-67-7 · dossier v0.1 · 24 Sept 2026
11 primary documents, each archived with a SHA-256 fingerprint · by route · where regulators disagree · legal limits · what our database has wrong · what we don't know.
Example rows: [S3] Commission Regulation (EU) 2022/63 · [S8] 29 CFR 1910.1000 Table Z-1 · [S4] CJEU Press Release No 99/25.
Example · titanium dioxide -
Know when the science moves.
Watch a list of substances; when a regulator reclassifies one, sets a new limit, or a court changes a ruling, you get the change and its source.
1 Aug 2025 · EU Court of Justice · Titanium dioxide (13463-67-7)
Appeals dismissed: the EU classification of certain titanium dioxide powders as "suspected of being carcinogenic to humans, by inhalation" stays annulled.
What it changes: safety data sheets and labels written while the classification applied may still carry it. · Source: CJEU Press Release No 99/25 [S4], archived.
Illustration of a planned alert; the change it reports is real -
We publish our own errors, and what we don’t know.
The correction directives open against the live properties, or not yet tied to one, are listed publicly; findings not yet placed in a directive are not on that list. Records that declare the data they lack come at launch.
Our record says The source says Status OSHA workplace limit: "Not established" until 29 September 2026, now "15 mg/m³" 15 mg/m³ total dust [S8] ✅ corrected 29 September 2026 to the Table Z-1 row (D-920) NIOSH limit: "Not established" until 29 September 2026, now 2.4 mg/m³ (fine) and 0.3 mg/m³ (ultrafine) 2.4 / 0.3 mg/m³ [S7] ✅ corrected 29 September 2026 to NIOSH CIB 63 (D-920) Sources: 13 citations the dossier cites 11 ⚠ only 2 of the dossier's 11 documents are matched to its sources We don't know: log Kow · LC50 · pKa · LOAEL (declared on the record) · pregnancy-specific evidence (not assessed).
Example · titanium dioxide
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Ecosystem
What We Build
Each platform serves a purpose. All of them serve you.
Safety
HQ Safety Database
Cited, source-traceable safety data on compounds, materials, and products. ALCOA+ data-integrity standards. Open and free.
API
ALETHEIA
Statistical safety aggregated record. Shows the full shape of regulatory consensus and disagreement — not collapsed answers.
Research
Research of Record
Rigorous, fully cited evidence syntheses, ungated. Not peer-reviewed. Topics include long-term PM2.5 exposure and Alzheimer's disease.
Visualization · Prototype
The Looking Glass
One compound, five dimensions: how severe the hazard is, how sure the evidence is, how recent, how sound the methods, how specific to the use. Glyphosate is the case study, because IARC, EPA and EFSA do not agree on it, and the picture shows where they part.